Ghana coach Otto Addo has made several changes to the team that lost to Brazil on Friday, including leaving Andre Ayew and Jordan Ayew on the bench for the friendly against Nicaragua.
Andre and his brother Jordan start on the bench, as do Baba Rahman and goalkeeper Jojo Wollacott.
Meanwhile, Alexander Djiku and Kamaldeen Sulemana, who both started against Brazil, are out with injuries.
Tariq Lamptey is also injured and will not play this evening.
Inaki Williams and Mohammed Salisu are among Otto Addo’s starters. When they came on in the second half against Brazil, the duo performed admirably.
Mohammed Kudus, Daniel Kofi Kyereh, and Baba Iddrisu start in midfield for the Black Stars.
Alidu Seidu starts at right back, Daniel Amartey at centre-back, and Richard Ofori comes in for Wollacott.
Gideon Mensah is the preferred left back, with Osman Bukari and Fatawu Issahaku supporting Inaki Williams up front.
The match began at 18:00 GMT in Lorca, Spain.